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Decoding the Effects of Bexarotene treatment on brain of AD-like model mice: Single-Cell Transcriptomics and Chromatin Accessibility Analysis

2025-08-13

Abstract excerpt

<title>Abstract</title> <p><bold>Backgound</bold>: Ligand-activated Retinoid X Receptors (RXRs) regulate gene networks essential for neural development, neuroinflammation, and metabolism. Understanding how RXR activation influences chromatin architecture and gene expression may reveal therapeutic strategies for neurodegenerative diseases. <bold>Methods</bold>: We used Bexarotene-treated APP/PS1ΔE9 mice to study R...

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Literature Corpus work: a3bab626-f574-599c-ae1f-075e2ffb9cfd
DOI: 10.21203/rs.3.rs-7201032/v1

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