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Article

Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer's Disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Jan 2025

Dunn Jessica, Moore Cedric, Kim Nam-Shik, Gao Tianshun, Cheng Zhiqiang, Jin Peng, Ming Guo-Li, Qian Jiang, Su Yijing, Song Hongjun, Zhu Heng

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with profound global impact. While genome-wide association studies (GWAS) have revealed genomic variants linked to AD, their translational impact has been limited due to challenges in interpreting the identified genetic associations. To address this challenge, we have devised a novel approach termed transcription factor-wide association studies...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39622643
DOI: 10.1523/JNEUROSCI.1800-24.2024
PMCID: PMC11714347

Genes

TF
SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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