Article

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer’s mouse model

2024-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Physical exercise represents a primary defense against age-related cognitive decline and neurodegenerative disorders like Alzheimer’s disease (AD). To impartially investigate the underlying mechanisms, we conducted single-nucleus transcriptomic and chromatin accessibility analyses (snRNA-seq and ATAC-seq) on the hippocampus of mice carrying AD-linked NL-G-F mutations in the amyloid precursor pro...

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Literature Corpus work: fa704e47-bbe2-5002-bb16-5e2971db0bf1
DOI: 10.1101/2024.05.02.592289

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