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Krüppel-like factors KLF5 & KLF8 emerge as master transcriptional regulators of Alzheimer’s disease, as revealed on cell fate regulomes in human brain organoids

2026-07-24

Abstract excerpt

<h4>SUMMARY</h4> In addition to the well described beta-amyloid plates accumulation and tau hyper-phosphorylation, Alzheimer’s disease (AD) is accompanied by major changes in gene expression. Herein, we aimed at revealing master transcription factors (TFs) responsible for gene expression changes during AD progression. For this, we have used human brain organoids (BORGs) harbouring AD-related genetic mutations (AP...

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Literature Corpus work: d031ca07-6cc7-5e12-bf28-92d1539fde81
DOI: 10.64898/2026.07.23.740401

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Krüppel-like factors KLF5 & KLF8 emerge as master transcriptional regulators of Alzheimer’s disease, as revealed on cell fate regulomes in human brain organoidsDOI 10.64898/2026.07.23.740401Read

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