Arc: a therapeutic hub for Alzheimer’s disease

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is poised to reach epidemic levels as the world population ages. There is currently no treatment that halts this debilitating disease. Our recent finding that the memory gene Arc regulates the expression of many genes associated with the pathophysiology of AD sets the stage for a new therapeutic approach that is not structurally based on the amyloid hypothesis that has d...

Topics

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• Alzheimer's disease research and treatments
• Autophagy in Disease and Therapy
• Cholinesterase and Neurodegenerative Diseases
• Epigenetics and DNA Methylation
• Histone Deacetylase Inhibitors Research
• Memory and Neural Mechanisms
• Neuroscience and Neuropharmacology Research
• Nuclear Receptors and Signaling

Identifiers and source

Literature Corpus work

d0d8a887-5908-5eb6-aa9f-c3945da17f8f

DOI

10.1101/2025.01.16.632170