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Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related Stages

23 Apr 2014

Abstract excerpt

Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown. Here, we aimed to elucidate relevant mechanisms responsible for transcriptional changes underlying early memory loss in AD by examining pathological, behavioral, and transcriptomic changes in...

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Alzheimer's disease research and treatments
Genetics and Neurodevelopmental Disorders
RNA Research and Splicing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24760838
DOI: 10.1523/jneurosci.5288-13.2014

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