Back to search

Article

Brain single-cell transcriptional responses to bexarotene-activated RXR in Alzheimer’s disease model

2025-07-31

Abstract excerpt

Pharmacological activation of brain Retinoid X Receptors (RXRs) enhances cognition and facilitates amyloid-beta (Aβ) clearance in Alzheimer’s disease (AD) mouse models, partly by upregulating Apolipoprotein E ( Apoe ), a major AD genetic risk factor. However, the specific cellular contributions to these effects are unclear. Here, we used single-cell transcriptomic profiling to investigate cell subpopulation-speci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d0e7199f-13e3-52ef-a4f1-4e74bd1ca9d2
DOI
10.1101/2025.07.25.666575
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Brain single-cell transcriptional responses to bexarotene-activated RXR in Alzheimer’s disease modelDOI 10.1101/2025.07.25.666575
RXR controlled regulatory networks identified in mouse brain counteract deleterious effects of Aβ oligomersSemantic proximity
Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway.Semantic proximity
Decoding the Effects of Bexarotene treatment on brain of AD-like model mice: Single-Cell Transcriptomics and Chromatin Accessibility AnalysisSemantic proximity
Comparative gene regulatory networks modulating <i>APOE</i> expression in microglia and astrocytesSemantic proximity
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease RiskSemantic proximity
Cholesterol and matrisome pathways dysregulated in human <i>APOE</i> ε4 gliaSemantic proximity
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.Semantic proximity
Liver X receptor agonist treatment significantly affects phenotype and transcriptome of APOE3 and APOE4 Abca1 haplo-deficient mice.Semantic proximity
Retinoid-X-Receptor as a Mediator of Poststroke Recovery by Reversing Age-Associated Phenotypes of Microglia/Hematogenous Macrophages.Semantic proximity
Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegenerationSemantic proximity
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease RiskSemantic proximity
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology.Semantic proximity
Select a neighboring publication to make it the new centre.