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Article

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine.

Pharmacogenetics and genomics - 1 Jul 2008

Wang Zhi-Jun, Yin Ophelia Q P, Tomlinson Brian, Chow Moses S S

Abstract excerpt

PURPOSE: Genetic polymorphisms of organic cation transporter 2 (OCT2) have been recently described, but their genotype-phenotype relationship in humans is unknown. We performed this study to (i) characterize genetic variations of the OCT2 gene in the Chinese population and (ii) investigate the potential functional significance of OCT2 polymorphisms using metformin (an OCT2 substrate) alone or in the presence of...

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PMID: 18551044
DOI: 10.1097/FPC.0b013e328302cd41

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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