Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans.

doi:10.1002/cpt.701

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Article

Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans.

Clinical pharmacology and therapeutics - 1 Nov 2017

Sundelin Eio, Gormsen L C, Jensen J B, Vendelbo M H, Jakobsen S, Munk O L, Christensen Mmh, Brøsen K, Frøkiaer J, Jessen N

Abstract excerpt

Metformin has been used successfully to treat type 2 diabetes for decades. However, the efficacy of the drug varies considerably from patient to patient and this may in part be due to its pharmacokinetic properties. The aim of this study was to examine if common polymorphisms in SLC22A1, encoding the transporter protein OCT1, affect the hepatic distribution of metformin in humans. We performed noninvasive 11...

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Share to Drug Transport and Resistance Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28380657
DOI: 10.1002/cpt.701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.