Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.

Drug metabolism and pharmacokinetics - 1 Jan 2008

Choi Min-Koo, Song Im-Sook

Abstract excerpt

To clarify the considerable interindividual variability in the pharmacokinetics, efficacy, and toxicity of drugs, genetic polymorphism of drug transporters has attracted interest because these transporters play important roles in the gastrointestinal absorption, biliary and renal elimination, and distribution to target sites of their substrates. Of the over 325 members of the solute carrier superfamily, this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Cisplatin
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Metformin

Share to Organic Cation Transport Proteins

Share to Piperazines

Share to Pyrimidines

Source

Identifiers

PMID: 18762711
DOI: 10.2133/dmpk.23.243

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences.PMID 18762711Read ↗

Genetic variation in organic cation transporters and considerations in drug development.Semantic proximity Read ↗

Organic cation transporters.Semantic proximity Read ↗

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug DispositionSemantic proximity Read ↗

Current understanding of the pharmacogenomics of metformin.Semantic proximity Read ↗

Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy.Semantic proximity Read ↗

Polymorphism in human organic cation transporters and metformin action.Semantic proximity Read ↗

Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics.Semantic proximity Read ↗

Organic cation transporter OCTs (SLC22) and MATEs (SLC47) in the human kidney.Semantic proximity Read ↗

Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology.Semantic proximity Read ↗

Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology.Semantic proximity Read ↗

Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy.Semantic proximity Read ↗

The human organic cation transporter OCT1 and its role as a target for drug responsesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.