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Article

The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition

10 Sept 2020

Abstract excerpt

A considerable number of drugs and/or their metabolites are excreted by the kidneys through glomerular filtration and active renal tubule secretion via transporter proteins. Uptake transporters in the proximal tubule are part of the solute carrier (SLC) superfamily, and include the organic cation transporters (OCTs). Several studies have shown that specific genetic polymorphisms in OCTs alter drug disposition and...

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PMID: 32927790
DOI: 10.3390/ijms21186627

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