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Article

Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes.

BMC endocrine disorders - 26 May 2022

Kawoosa Fizalah, Shah Zafar A, Masoodi Shariq R, Amin Asif, Rasool Roohi, Fazili Khalid M, Dar Abid Hamid, Lone Asif, Ul Bashir Samir

Abstract excerpt

BACKGROUND: Organic cation transporter 1 primarily governs the action of metformin in the liver. There are considerable inter-individual variations in metformin response. In light of this, it is crucial to obtain a greater understanding of the influence of OCT1 expression or polymorphism in the context of variable responses elicited by metformin treatment. RESULTS: We observed that the variable response to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35619086
DOI: 10.1186/s12902-022-01033-3
PMCID: PMC9137212

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