Article
Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol.
Systematic reviews - 25 Jul 2018
Mato Edith Pascale Mofo, Guewo-Fokeng Magellan, Faadiel Essop M, Owira Peter Mark Oroma
Abstract excerpt
BACKGROUND: Metformin is one of the most commonly used drugs for type 2 diabetes mellitus (T2DM). Despite its efficacy and safety, metformin is frequently associated with highly variable glycemic responses, which is hypothesized to be the result of genetic variations in its transport by organic cation transporters (OCTs). This systematic review aims to highlight and summarize the overall effects of OCT1...
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