Article

Allosteric Mechanisms Underlying Long QT Syndrome Type 2 (LQT2)-Associated Mutations in hERG Channels

2026-04-07

Abstract excerpt

1 Long QT syndrome Type 2 (LQT2) is a genetic disorder caused by missense mutations in the KCNH2 gene that encodes the potassium channel K V 11.1. Previous studies have shown that most K V 11.1 missense mutations with loss-of-function phenotypes result from impaired trafficking from the endoplasmic reticulum to the plasma membrane. To investigate the molecular basis of these defects, we used molecular dynamics s...

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Literature Corpus work: a3948d7c-9284-56d6-ba31-b3e92000de46
DOI: 10.64898/2026.04.05.715988

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