Article
Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
Biophysical journal - 24 Mar 2015
Perissinotti Laura L, Guo Jiqing, De Biase Pablo M, Clancy Colleen E, Duff Henry J, Noskov Sergei Y
Abstract excerpt
Congenital and acquired (drug-induced) forms of the human long-QT syndrome are associated with alterations in Kv11.1 (hERG) channel-controlled repolarizing IKr currents of cardiac action potentials. A mandatory drug screen implemented by many countries led to a discovery of a large group of small molecules that can activate hERG currents and thus may act as potent antiarrhythmic agents. Despite significant...
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