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Article

Conformational changes in the selectivity filter of the open-state KcsA channel: an energy minimization study.

Biophysical journal - 1 Oct 2008

Miloshevsky Gennady V, Jordan Peter C

Abstract excerpt

Potassium channels switch between closed and open conformations and selectively conduct K(+) ions. There are at least two gates. The TM2 bundle at the intracellular site is the primary gate of KcsA, and rearrangements at the selectivity filter (SF) act as the second gate. The SF blocks ion flow via an inactivation process similar to C-type inactivation of voltage-gated K(+) channels. We recently generated the...

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Identifiers

PMID: 18621821
DOI: 10.1529/biophysj.108.136556
PMCID: PMC2547464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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