Article

Molecular Insights into the Rescue Mechanism of an hERG Activator Against Severe LQT2 Mutations.

2024-03-15

Abstract excerpt

Mutations in the hERG potassium channel are a major cause of long QT syndrome type 2 (LQT2), which can lead to sudden cardiac death. The hERG channel plays a critical role in the repolarization of the myocardial action potential, and loss-of-function mutations prolong cardiac repolarization. In this study, we investigated the efficacy and mechanism of ICA-105574, an hERG activator, in shortening the duration of ca...

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Literature Corpus work: c98b96c6-2e80-55b0-abf9-b2585a4a2ed5
DOI: 10.1101/2024.03.13.584147

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