Article
K+ channel selectivity depends on kinetic as well as thermodynamic factors.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2006
Grabe Michael, Bichet Delphine, Qian Xiang, Jan Yuh Nung, Jan Lily Yeh
Abstract excerpt
Potassium channels are necessary for a number of essential biological tasks such as the generation of action potentials and setting the resting membrane potential in cells, both of which require that these channels selectively permit the passage of potassium ions while suppressing the flow of other ions. Generally, this selectivity is attributed to a narrow stretch of the channel known as the selectivity filter....
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