Article

Energetic cross-talk of filter gate and lower helices drives polymodal regulation and disease in TREK K2P channels

2026-02-14

Abstract excerpt

The TREK subfamily of two-pore domain potassium (K 2P ) channels are essential regulators of membrane excitability, and their activity is modulated by a wide range of physiological stimuli, including phosphorylation and membrane stretch. Single-site mutations in this subfamily have been identified in patients with FHEIG symptom (facial dysmorphism, hypertrichosis, epilepsy, intellectual disability/developmental d...

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Literature Corpus work: 646e4f5e-6859-59d6-9fa2-e903efdb1562
DOI: 10.64898/2026.02.13.705734

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