Article
The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.
Biophysical journal - 6 Dec 2022
Kudaibergenova Meruyert, Guo Jiqing, Khan Hanif M, Lees-Miller James, Mousaei Mahdi, Miranda Williams, Ngo Van A, Noskov Sergei Yu, Tieleman D Peter, Duff Henry J
Abstract excerpt
A cationic leak current known as an "omega current" may arise from mutations of the first charged residue in the S4 of the voltage sensor domains of sodium and potassium voltage-gated channels. The voltage-sensing domains (VSDs) in these mutated channels act as pores allowing nonspecific passage of cations, such as Li+, K+, Cs+, and guanidinium. Interestingly, no omega currents have been previously detected in...
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