Article

Potassium dependent structural changes in the selectivity filter of HERG potassium channels

2023-12-15

Abstract excerpt

The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go related gene (HERG) potassium channels have uniquely rapid inactivation kinetics which are critical to the role they play in regulating cardiac electrical activity. Here, we have exploited the K + sensitivity of HERG ina...

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Literature Corpus work: 5495a680-1592-5297-b1ad-f8af325c19e6
DOI: 10.1101/2023.12.14.571769

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