Article

Molecular dynamics of the pathogenic KCNQ2 variant G256W reveal mechanisms of channel dysfunction in epileptic encephalopathy

2025-12-03

Abstract excerpt

Brain voltage-gated potassium channels containing the subunit KCNQ2 are essential for regulating electrical signals contributing to sensation, learning, memory, and motor control. De novo KCNQ2 variants are among the more common Mendelian causes of early life epilepsy and neurodevelopmental impairment. Some patients with KCNQ2 variants are affected with KCNQ2 developmental and epileptic encephalopathy ( KCNQ2...

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Literature Corpus work: 0ca6a7d0-31c8-53f1-8e37-c55331ac039a
DOI: 10.64898/2025.12.01.691689

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