Article
The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.
The Journal of biological chemistry - 9 Jan 2009
Ju Pengchu, Pages Guilhem, Riek R Peter, Chen Po-Chia, Torres Allan M, Bansal Paramjit S, Kuyucak Serdar, Kuchel Philip W, Vandenberg Jamie I
Abstract excerpt
Ion flow in many voltage-gated K(+) channels (VGK), including the (human ether-a-go-go-related gene) hERG channel, is regulated by reversible collapse of the selectivity filter. hERG channels, however, exhibit low sequence homology to other VGKs, particularly in the outer pore helix (S5) domain, and we hypothesize that this contributes to the unique activation and inactivation kinetics in hERG K(+) channels that...
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