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Article

Prediction of Kv11.1 potassium channel PAS-domain variants trafficking via machine learning.

Journal of molecular and cellular cardiology - 1 Jul 2023

Immadisetty Kalyan, Fang Xuan, Ramon Geraldine San, Hartle Cassandra M, McCoy Thomas P, Center Regeneron Genetics, Mirshahi Tooraj, Delisle Brian P, Kekenes-Huskey Peter M

Abstract excerpt

Congenital long QT syndrome (LQTS) is characterized by a prolonged QT-interval on an electrocardiogram (ECG). An abnormal prolongation in the QT-interval increases the risk for fatal arrhythmias. Genetic variants in several different cardiac ion channel genes, including KCNH2, are known to cause LQTS. Here, we evaluated whether structure-based molecular dynamics (MD) simulations and machine learning (ML) could...

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PMID: 37187232
DOI: 10.1016/j.yjmcc.2023.05.002

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