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IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastoma

2024-04-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Glioblastoma (GBM) has a highly immunosuppressive tumor immune microenvironment (TIME), largely mediated by myeloid-derived suppressor cells (MDSCs). Here, we utilized a retroviral replicating vector (RRV) to deliver Interferon Regulatory Factor 8 (IRF8), a master regulator of type 1 conventional dendritic cell (cDC1) development, in a syngeneic murine GBM model. We hypothes...

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Literature Corpus work
a305daf4-c3b9-5117-a1af-1644ca192e5a
DOI
10.1101/2024.04.02.587608
Open publication

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IRF8-driven reprogramming of the immune microenvironment enhances anti-tumor adaptive immunity and reduces immunosuppression in murine glioblastomaDOI 10.1101/2024.04.02.587608
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