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Article

Role of type 1 IFNs in antiglioma immunosurveillance--using mouse studies to guide examination of novel prognostic markers in humans.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2010

Fujita Mitsugu, Scheurer Michael E, Decker Stacy A, McDonald Heather A, Kohanbash Gary, Kastenhuber Edward R, Kato Hisashi, Bondy Melissa L, Ohlfest John R, Okada Hideho

Abstract excerpt

PURPOSE: We hypothesized that the type 1 IFNs would play a pivotal role in antiglioma immunosurveillance through promotion of type 1 adaptive immunity and suppression of immunoregulatory cells. EXPERIMENTAL DESIGN: We induced de novo gliomas in Ifnar1(-/-) (deficient for type 1 IFN receptors) or wild-type mice by intracerebroventricuar transfection of NRas and a short hairpin RNA against P53 using the Sleeping...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20472682
DOI: 10.1158/1078-0432.CCR-10-0644
PMCID: PMC2896455

Genes

IFNA8
IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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