Article

Exploring the immune environment of glioblastoma through single-cell RNA sequencing in humanized mouse models

2025-05-22

Abstract excerpt

<h4>Background: </h4> Glioblastoma (GBM) is the deadliest primary brain tumor in adults, where current therapies fail to meaningfully extend survival. Available animal GBM tumor models, especially therapy-resistant and recurrent ones with unique immunological aspects, are restricted, impeding innovative treatment research. To confront this critical obstacle we established a unique GBM mouse model that utilizes pat...

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Literature Corpus work: 8c5dfc29-87f7-56c7-ba5d-990b55d4bcb3
DOI: 10.1101/2025.05.17.654526

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