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IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma

2025-03-14

Abstract excerpt

The glioblastoma tumor immune microenvironment (TIME) is an immunosuppressive barrier to therapy that encumbers glioblastoma responses to immune checkpoint inhibition (ICI). Immunosuppressive cytokines, pro-tumor myeloid cells, and exhausted T-cells are hallmarks of the glioblastoma TIME. Here we integrate spatial and single-cell analyses of patient-matched human glioblastoma samples before and after ICI with gene...

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Literature Corpus work
fa75f848-6879-57ad-ba04-2e37c084bbab
DOI
10.1101/2025.03.12.642800
Open publication

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IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastomaDOI 10.1101/2025.03.12.642800
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