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Spatiotemporal dynamics of adoptively transferred stem-like CD8 <sup>+</sup> T cells in the tumor microenvironment following vaccination

2026-05-14

Abstract excerpt

Adoptive cell therapy (ACT) of tumor-specific T cells can improve survival in a subset of cancer patients. Current ACT approaches may be limited by using highly differentiated T cells which can be inhibited by an immunosuppressive tumor microenvironment (TME). Here, we developed an approach to optimize ACT and used spatial transcriptomics to show how stem-like and effector CD8 + T cells differentially mediate tum...

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Literature Corpus work
b34a7d4f-dc37-5b71-841e-cbd3a79d67b8
DOI
10.64898/2026.05.12.724323
Open publication

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Spatiotemporal dynamics of adoptively transferred stem-like CD8 <sup>+</sup> T cells in the tumor microenvironment following vaccinationDOI 10.64898/2026.05.12.724323
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