Article

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

2020-12-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Glioblastoma (GBM) is refractory to checkpoint blockade immunotherapy (CPI). We sought to determine to what extent this immune evasion is due to intrinsic properties of the tumor cells versus the specialized immune context of the brain, and if it can be reversed. <h4>Methods</h4> We used CyTOF mass cytometry to compare the tumor immune microenvironments (TIME) of human tumo...

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Identifiers and source

Literature Corpus work: 9193b56f-ee6f-599a-9710-035277ea1c10
DOI: 10.1101/2020.12.01.404939

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