Article

Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma

2024-10-17

Abstract excerpt

Glioblastoma (GBM) is the most lethal primary brain neoplasm due to its highly immunosuppressive microenvironment and resistance to conventional therapies. To overcome this challenge, we engineered a replicating retrovirus (RRV) to deliver a superagonist interleukin-15 receptor-linked fusion protein (RLI) directly to tumor cells, engineering them into local immunotherapy biofactories. This strategy leverages the t...

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Identifiers and source

Literature Corpus work: 92427260-3d58-5106-97af-e74ec93bfd1b
DOI: 10.1101/2024.10.14.618095

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