Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization.

Cell reports - 28 Oct 2025

Fan Yang, Yin Hang, Zhao Jing, Yao Bolin, Cheng Guangli, Yang Yaqi, Yang Minghao, Chen Luo, Chen Jian, Zhou Ji, Li Ren, Zhao Botao, Zhang Xiao-Yong, Wang Cong, Gao Xihui, Li Cong

Abstract excerpt

Glioblastoma (GBM) is a highly lethal brain tumor resistant to immunotherapy due to poor brain drug delivery and an immunosuppressive microenvironment. This study introduces a macrophage-based adoptive cell therapy that reprograms the tumor immune landscape to suppress GBM growth. We reveal that macrophage homing to GBM is phenotype-dependent, with anti-inflammatory macrophages more efficiently navigating the...

Read the complete abstract on PubMed

Topics

Glioblastoma
Animals
Tumor Microenvironment
Mice
Macrophages
Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Brain Neoplasms

Phenotype

Cell Line, Tumor

Mice, Inbred C57BL

Immunotherapy, Adoptive

Source

Identifiers

PMID: 41014558
DOI: 10.1016/j.celrep.2025.116350

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adoptive macrophages suppress glioblastoma growth by reversing immunosuppressive microenvironment through programmed phenotype repolarization.PMID 41014558Read ↗

Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implicationsSemantic proximity Read ↗

Macrophages/Microglia in the Glioblastoma Tumor MicroenvironmentSemantic proximity Read ↗

Tumor progression is independent of tumor-associated macrophages in cell lineage–based mouse models of glioblastomaSemantic proximity Read ↗

Immune Microenvironment in Glioblastoma Subtypes.Semantic proximity Read ↗

Chemoradiation-Altered Micromilieu of Glioblastoma Cells Particularly Impacts M1-Like Macrophage ActivationSemantic proximity Read ↗

In vitro generated macrophages reflect the immunosuppressive phenotype of in vivo glioblastoma-associated macrophages.Semantic proximity Read ↗

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity Read ↗

Genetically modified IL-2 bone marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironmentSemantic proximity Read ↗

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights tumor-promoting macrophage cells in GlioblastomaSemantic proximity Read ↗

Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cellsSemantic proximity Read ↗

Integrin blocking peptide reverses immunosuppression in experimental gliomas and improves anti-PD-1 therapy outcomeSemantic proximity Read ↗

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.