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A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical Models

2024-12-21

Abstract excerpt

<h4>Background</h4> Bispecific T cell-engagers (BTEs) are engineered antibodies that redirect T cells to target antigen-expressing tumors. BTEs targeting tumor-specific antigens such as interleukin 13 receptor alpha 2 (IL13Rα2) and EGFRvIII have been developed for glioblastoma (GBM). However, there is limited mechanistic understanding of the action of BTE since prior studies were mostly conducted in immunocomprom...

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Literature Corpus work
cf3a0123-f7a3-54f5-b3a9-5d3f869e4d12
DOI
10.1101/2024.12.18.628714
Open publication

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A Bi-Specific T Cell-Engaging Antibody Triggers Protective Immune Memory and Glioma Microenvironment Remodeling in Immune Competent Preclinical ModelsDOI 10.1101/2024.12.18.628714
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