Article

Molecular rotors provide insight into the mechanism of formation and conversion of <i>α</i> -synuclein aggregates

2024-09-14

Abstract excerpt

<h4>ABSTRACT</h4> α -Synuclein is an intrinsically disordered protein that forms amyloids in Parkinson’s disease. Currently, detection methods predominantly report on the formation of mature amyloids but have poor sensitivity to the early-stage, toxic oligomers. Molecular rotors are fluorophores that sense changes in the viscosity of their local environment. Here, we monitor α -synuclein oligomer formation using...

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Literature Corpus work: a2bfb3e9-f5a2-536c-b384-6dfbfe42134e
DOI: 10.1101/2024.09.13.612428

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