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Article

Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2012

Ahmad Basir, Chen Yujie, Lapidus Lisa J

Abstract excerpt

We hypothesize that the first step of aggregation of disordered proteins, such as α-synuclein, is controlled by the rate of backbone reconfiguration. When reconfiguration is fast, bimolecular association is not stable, but as reconfiguration slows, association is more stable and subsequent aggreg...

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Identifiers

PMID: 22308332
DOI: 10.1073/pnas.1109526109
PMCID: PMC3289313

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22308332-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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