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Article

Residue-specific fluorescent probes of α-synuclein: detection of early events at the N- and C-termini during fibril assembly.

Biochemistry - 29 Mar 2011

Yap Thai Leong, Pfefferkorn Candace M, Lee Jennifer C

Abstract excerpt

In the Parkinson's disease-associated state, α-synuclein undergoes large conformational changes, forming ordered, β-sheet-containing fibrils. To unravel the role of specific residues during the fibril assembly process, we prepared single-Cys mutants in the disordered (G7C and Y136C) and proximal (V26C and L100C) fibril core sites and derivatized them with environmentally sensitive dansyl (Dns) fluorophores. Dns...

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PMID: 21338068
DOI: 10.1021/bi2000824
PMCID: PMC3074234

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