Article

Biophysical approaches to characterising protein-protein interactions and intermediate species in protein aggregation

2020-01-01

Abstract excerpt

The phenomenon of protein misfolding and aggregation has been associated with over 50 human diseases, including Parkinson's disease (PD). While the hallmark deposits in aggregation-associated diseases are primarily composed of fibrillar species, intermediate oligomeric species that form during the aggregation process are believed to be a major cause of toxicity. Such species are relatively poorly characterised due...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 48247309-ca23-5044-bf07-8b24869aa12d
DOI: 10.17863/cam.65349

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biophysical approaches to characterising protein-protein interactions and intermediate species in protein aggregationDOI 10.17863/cam.65349Read

An interdisciplinary approach to studying mechanistic, structural and toxic features of protein aggregates associated with neurodegenerative disordersSemantic proximity Read

Mechanistic Models of Protein Aggregation Across Length-Scales and Time-Scales: From the Test Tube to Neurodegenerative DiseaseSemantic proximity Read

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseasesSemantic proximity Read

Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions.Semantic proximity Read

Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregationSemantic proximity Read

Mitigating protein aggregation to reduce the toxicity inherent to Parkinson's and Alzheimer's diseasesSemantic proximity Read

Structural mechanisms of oligomer and amyloid fibril formation by the prion protein.Semantic proximity Read

Immuno-based detection assays to quantify distinct mutant huntingtin conformations in biological samples.Semantic proximity Read

Molecular determinants of protein pathogenicity at the single-aggregate levelSemantic proximity Read

Neurotoxic protein oligomerisation associated with polyglutamine diseases.Semantic proximity Read

Multiplicity of α-Synuclein Aggregated Species and Their Possible Roles in DiseaseSemantic proximity Read

Neurodegenerative disorders of protein aggregationSemantic proximity Read