Article

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

2019-12-08

Abstract excerpt

Aggregation of α-synuclein is a defining molecular feature of Parkinson’s disease, Lewy Body Dementia, and Multiple Systems Atrophy. Hereditary mutations in α-synuclein are linked to both Parkinson’s disease and Lewy Body Dementia; in particular, patients bearing the E46K disease mutation manifest a clinical picture of parkinsonism and Lewy Body Dementia, and E46K creates more pathogenic fibrils in vitro. Underst...

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Literature Corpus work: 8b61983d-7ad9-586c-b151-dbd3a276cffc
DOI: 10.1101/868869

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