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Article

Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants.

The Journal of biological chemistry - 30 Dec 2005

Ulmer Tobias S, Bax Ad

Abstract excerpt

Three point mutations (A30P, E46K, and A53T) as well as gene triplication genetically link the 140-residue protein alpha-synuclein (aS) to the development of Parkinson disease. Here, the structure and dynamics of micelle-bound aS(A30P) and aS(A53T) are described and compared with wild-type aS, in addition to describing the aS-micelle interaction. A53T is sensed only by directly adjacent residues and leaves the...

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Identifiers

PMID: 16166095
DOI: 10.1074/jbc.M507624200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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