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Article

Molecular Rotors Detect the Formation and Conversion of α-Synuclein Oligomers.

ACS applied materials & interfaces - 19 Feb 2025

Allerton Siân C, Kuimova Marina K, Aprile Francesco A

Abstract excerpt

α-Synuclein is an intrinsically disordered protein that forms amyloids in Parkinson's disease. Currently, detection methods predominantly report on the formation of mature amyloids but are weakly sensitive to the early stage, toxic oligomers. Molecular rotors are fluorophores that sense changes in the viscosity of their local environment. Here, we monitor α-synuclein oligomer formation using the fluorescence...

Read the complete abstract on PubMed

Topics

alpha-Synuclein
Humans
Parkinson Disease
Amyloid
Protein Multimerization
Fluorescent Dyes
Mutation

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Identifiers

PMID: 39907186
DOI: 10.1021/acsami.4c21710
PMCID: PMC11843532

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