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Article

Unfolding Sequence-Specific Enigma in Monomeric α-Synuclein: Implications for Parkinson's Disease.

ACS chemical neuroscience - 7 Jan 2026

Ranjan Priyatosh, Kumar Ashutosh

Abstract excerpt

Parkinson's disease (PD) is a debilitating neurological disorder characterized by the buildup of abnormal protein clumps, primarily composed of a protein called Alpha-Synuclein (α-Syn). Under physiological conditions, α-Syn exists as a dynamic, intrinsically disordered protein that resists aggregation through transient intramolecular interactions. However, under pathological conditions, this protein can misfold...

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PMID: 41410608
DOI: 10.1021/acschemneuro.5c00423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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