Article

<i>In vitro</i> -prepared A30P alpha-synuclein fibrils adopt the conserved and disease-relevant Greek key fold

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> The pathological hallmark of Parkinson Disease (PD) is the formation of the protein alpha-synuclein (Asyn) into β-sheet rich, self-templating fibrils in the brain. Since the first atomic structure of wild-type Asyn fibrils was determined nearly a decade ago, several other in vitro structures of hereditary mutant fibrils and structures derived from post-mortem diseased patient tissue have been d...

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Literature Corpus work: d117c3f4-2db9-5f55-ae9c-e42fe9c7999c
DOI: 10.64898/2026.02.03.703603

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