Article

Genetic Factor Analysis for Characterizing Phenome-Wide Patterns of Genetic Pleiotropy

2024-07-22

Abstract excerpt

<title>Abstract</title> <p>Genetic associations shared by multiple traits provide evidence about the biological role of disease associated variants. We propose Genetic Factor Analysis (GFA), a multi-phenotype analysis method that identifies common patterns of cross-trait associations, the signatures of shared biological processes. GFA overcomes many limitations of alternative methods by automatically selecting th...

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Literature Corpus work: a28be7fa-235e-5cdd-9bbf-502ea56af1ec
DOI: 10.21203/rs.3.rs-4714610/v1

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