Article

Polygenic risk modeling with latent trait-related genetic components

2019-10-17

Abstract excerpt

Polygenic risk models have led to significant advances in understanding complex diseases and their clinical presentation. While models like polygenic risk scores (PRS) can effectively predict outcomes, they do not generally account for disease subtypes or pathways which underlie within-trait diversity. Here, we introduce a latent factor model of genetic risk based on components from Decomposition of Genetic Associ...

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Literature Corpus work: 693f58b8-5129-5b3f-9067-ea9416da821e
DOI: 10.1101/808675

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