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Article

Polygenic risk modeling with latent trait-related genetic components.

European journal of human genetics : EJHG - 1 Jul 2021

Aguirre Matthew, Tanigawa Yosuke, Venkataraman Guhan Ram, Tibshirani Rob, Hastie Trevor, Rivas Manuel A

Abstract excerpt

Polygenic risk models have led to significant advances in understanding complex diseases and their clinical presentation. While polygenic risk scores (PRS) can effectively predict outcomes, they do not generally account for disease subtypes or pathways which underlie within-trait diversity. Here, we introduce a latent factor model of genetic risk based on components from Decomposition of Genetic Associations...

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Identifiers

PMID: 33558700
DOI: 10.1038/s41431-021-00813-0
PMCID: PMC8298449

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