Article

Shared components of heritability across genetically correlated traits

2021-11-30

Abstract excerpt

Most disease-associated genetic variants are pleiotropic, affecting multiple genetically correlated traits. Their pleiotropic associations can be mechanistically informative: if many variants have similar patterns of association, they may act via similar pleiotropic mechanisms, forming a shared component of heritability. We developed Pleiotropic Decomposition Regression (PDR) to identify shared components and thei...

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Literature Corpus work: 6a52d23a-418a-5b8b-bdae-360c3b0f8bdc
DOI: 10.1101/2021.11.25.470021

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