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Article

Shared components of heritability across genetically correlated traits.

American journal of human genetics - 2 Jun 2022

Ballard Jenna Lee, O'Connor Luke Jen

Abstract excerpt

Most disease-associated genetic variants are pleiotropic, affecting multiple genetically correlated traits. Their pleiotropic associations can be mechanistically informative: if many variants have similar patterns of association, they may act via similar pleiotropic mechanisms, forming a shared component of heritability. We developed pleiotropic decomposition regression (PDR) to identify shared components and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35477001
DOI: 10.1016/j.ajhg.2022.04.003
PMCID: PMC9247834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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