Article

Phenome-wide search for pleiotropic loci highlights key genes and molecular pathways for human complex traits

2019-06-16

Abstract excerpt

Over recent decades, genome-wide association studies (GWAS) have dramatically changed the understanding of human genetics. A recent genetic data release by UK Biobank has allowed many researchers worldwide to have comprehensive look into the genetic architecture of thousands of human phenotypes. In this study, we developed a novel statistical framework to assess phenome-wide significance and genetic pleiotropy acr...

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Literature Corpus work: 318a13ea-0c33-570e-8803-98307cd80357
DOI: 10.1101/672758

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