The omnicausal model reveals the highly polyfactorial nature of complex diseases

Abstract excerpt

Mendelian Randomization (MR) is a human genetics method for inferring causal relationships between risk factors and diseases. A common focus of MR studies has been on the causal inference of a single risk factor on a single disease. This has led to the successful discovery of numerous causal risk factors for disease. However, it remains unclear how much each causal risk factor contributes to disease collectively....

Topics

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• Causality
• Computer Simulation
• Genetic Predisposition to Disease
• Mendelian Randomization Analysis
• Models, Genetic
• Principal Component Analysis
• Risk Factors
• Schizophrenia

Identifiers and source

Literature Corpus work

320d89d1-8139-51e5-bf7c-ed69473de216

DOI

10.1101/2025.08.20.25333988