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Article

A framework to decipher the genetic architecture of combinations of complex diseases: applications in cardiovascular medicine.

Bioinformatics (Oxford, England) - 18 Nov 2021

Yin Liangying, Chau Carlos Kwan-Long, Lin Yu-Ping, Rao Shitao, Xiang Yong, Sham Pak-Chung, So Hon-Cheong

Abstract excerpt

MOTIVATION: Currently, most genome-wide association studies (GWAS) are studies of a single disease against controls. However, an individual is often affected by more than one condition. For example, coronary artery disease (CAD) is often comorbid with type 2 diabetes mellitus (T2DM). Similarly, it is clinically meaningful to study patients with one disease but without a related comorbidity. For example, obese...

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PMID: 34050728
DOI: 10.1093/bioinformatics/btab417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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